The phosphate salt of codeine happens as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in water and marginally soluble in Alcoholic beverages. The molecular bodyweight is 406.37. Its molecular components is C18H21NO3•H3PO4 • ½ H2O, and it's got the next chemical structure.

Unresponsive Cough The dosage of Promethazine with Codeine Oral Alternative shouldn't be elevated if cough fails to reply; an unresponsive cough ought to be reevaluated in five days or quicker for feasible underlying pathology, for instance foreign entire body or lessen respiratory tract ailment [ see Dosage and Administration ( 2.three) ]. Asthma and various Pulmonary Illness The usage of Promethazine with Codeine Oral Remedy in people with acute or intense bronchial asthma within an unmonitored environment or while in the absence of resuscitative devices is contraindicated [ see Contraindications ( 4) ]. Opioid analgesics and antitussives, which includes codeine, one of the Lively substances in Promethazine with Codeine Oral Resolution, shouldn't be used in people with acute febrile disease related with productive cough or in patients with Long-term respiratory illness in which interference with power to distinct the tracheobronchial tree of secretions might have a deleterious effect on the individual’s respiratory purpose. Promethazine with Codeine Oral Answer -addressed individuals with sizeable Serious obstructive pulmonary disease or cor pulmonale, and people with a significantly reduced respiratory reserve, hypoxia, hypercapnia, or pre-current respiratory melancholy are at amplified hazard of lessened respiratory generate such as apnea, even at proposed dosages of Promethazine with Codeine Oral Remedy [ see Warnings and Safeguards ( 5.

Promethazine hydrochloride takes place to be a white to faint yellow, basically odorless, crystalline powder which slowly oxidizes and turns blue on extended publicity to air.

Get medical support right away in case you see any of the following: sluggish/shallow respiration, critical drowsiness/difficulty waking up, confusion.

CONDITIONS OF USE: The data In this particular databases is meant to complement, not substitute for, the know-how and judgment of Health care industry experts. The knowledge just isn't intended to cover all achievable employs, directions, safety measures, drug interactions or adverse effects, nor need to or not it's construed to point that utilization of a selected drug is safe, appropriate or successful in your case or any one else.

This is simply not an entire list of probable side effects. When you read more recognize other Unwanted side effects not mentioned previously mentioned, contact your doctor or pharmacist.

No evidence of tumorigenicity was observed in male and woman mice at codeine dietary doses up to 400 mg/kg/working day (close to comparable to forty five periods the MRHD on the mg/m2 foundation).

Carcinogenicity reports have been performed with codeine. Two-year scientific tests in F344/N rats and B6C3F1 mice were done to evaluate the carcinogenic probable of codeine. No proof of tumorigenicity was noticed in male and feminine rats at codeine dietary doses approximately 70 and 80 mg/kg/day (somewhere around such as 15 and twenty moments, the MRHD on the mg/m2 basis, respectively).

Asthma Along with other Respiratory Disorders: Narcotic analgesics or cough suppressants, including codeine, should not be used in asthmatic individuals (see CONTRAINDICATIONS). Nor must they be Utilized in acute febrile disease affiliated with effective cough or in Persistent respiratory disease exactly where interference with capability to distinct the tracheobronchial tree of secretions would have a deleterious impact on the affected individual’s respiratory functionality.

To help stop withdrawal, your health practitioner may perhaps lower your dose gradually. Withdrawal is more most likely For those who have employed this medication for years (quite a lot of weeks) or in superior doses. Notify your health practitioner or pharmacist at once When you've got withdrawal.

Make use of other supportive steps (such as oxygen and vasopressors) within the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require Sophisticated daily life-aid techniques. Gastric emptying can be handy in eradicating unabsorbed drug.

Administration of codeine may very well be accompanied by histamine release and may be made use of with warning in atopic youngsters.

Making use of this medicine with other prescription drugs that slow your breathing may cause dangerous Unwanted effects or Loss of life. Ask your physician before applying opioid medication, a sleeping tablet, a muscle relaxer, or drugs for panic or seizures.

It really is utilized to relieve coughing. It truly is accustomed to simplicity allergy indications. It's utilized to ease chilly indications. What do I need to tell my physician BEFORE I acquire Promethazine and Codeine?